Association of two loci on chromosome 2q with nodal osteoarthritis.
نویسندگان
چکیده
منابع مشابه
Association of two loci on chromosome 2q with nodal osteoarthritis.
OBJECTIVE To search for genetic association between microsatellite marker loci and sibling pairs with nodal osteoarthritis (NOA). METHODS Using the affected sibling pair method of analysis, genomic DNA from 66 sib pairs with NOA was analysed for association with highly polymorphic microsatellite marker loci. The microsatellite markers were amplified using polymerase chain reaction and typed o...
متن کاملLinkage analysis of chromosome 2q in osteoarthritis.
BACKGROUND In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA). OBJECTIVE To test chromosome 2q for linkage to idiopathic osteoarthritis. METHODS Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage dise...
متن کاملMapping NIDDM susceptibility loci in French families: studies with markers in the region of NIDDM1 on chromosome 2q.
Hanis et al. (1) have recently reported the mapping of a major susceptibility locus for NIDDM to human chromosome 2q37 in Mexican-Americans through a genomewide linkage scan. They have provided evidence that this locus is linked to NIDDM and may account for 30% of the familial clustering of NIDDM in this population. They have proposed that this locus be designated NIDDM1. Lander and Kruglyak (2...
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BACKGROUND Previous studies have suggested a strong genetic component to osteoarthritis (OA), especially that of the hand, and three linkage studies have suggested the existence of susceptibility loci in disparate regions of chromosome 2q. OBJECTIVE To examine for linkage to 2q in a Tasmanian population of women and men with familial hand OA. METHODS Hand OA (distal interphalangeal, carpome...
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Several genes directly related to thyroid cancer development have been described; nevertheless, the genetic pathways of this tumorigenesis process are unknown. Together with environmental factors, susceptibility genes could have an important role in thyroid cancer. Our previous studies suggest that the chromosome 1p12-13 is related to thyroid cancer incidence. Here, we extend the analysis with ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1996
ISSN: 0003-4967
DOI: 10.1136/ard.55.5.317